A marrow chromosomal abnormality preceding clinical leukemia in Down's syndrome.
نویسندگان
چکیده
By ALAN P. DEMAYO, KOSMAS A. KIosSoGLoU, MARION E. ERLANDSON, REBECCA F. NOTTERMAN AND JAMES GERMAN DETECTION OF THE LEUKEMIC PROCESS before the usual clinical and hematologic features have appeared could be of value not only from the therapeutic standpoint but also in the understanding of the pathogenesis and evolution of the disease. In this respect, a better understanding of Down’s syndrome ( mongolism ) may become of importance, because this disorder is characterized by abnormalities of the leukocytes”2 and an increased tendency to leukemia.3 In an unselected group of individuals affected with Down’s syndrome, some may therefore manifest the earliest stages of leukemia. The present study describes the incidental discovery of an abnormal stemline cell in the bone marrow of a mongol 2#{189} months before the development of clinical leukemia as recognized by the usual hematologic criteria. Such a finding implies that chromosomal analyses may occasionally be helpful in detecting and studying the early stages of leukemia.
منابع مشابه
DNA-Repair Capacity in Down\'s Syndrome
Down's syndrome (DS) is the most common chromosomal abnormality in human. Subjects with DS are known to be peridisposed to develop leukemia. The molecular basis of the association between DS and leukemia is unknown. The unscheduled DNA synthesis (UDS) test measure the ability of DNA-repair in mammalian cells after excision of a stretch of DNA containing the region of damage induced by chemical ...
متن کاملDicentric chromosome in the bone marrow of a child with megakaryoblastic leukaemia and Down's syndrome.
A two year old girl with Down's syndrome (constitutional karyotype: 47 + 21), presenting with pancytopenia, developed acute megakaryoblastic leukaemia (AMKL). Her bone marrow contained an abnormal clone with a novel dicentric chromosome derived from chromosomes 5 and 7 (karyotype 46, XX, -5, -7, +dic (5;7) (p 13; p 11.2), +21. This case provides further evidence for a connection between chromos...
متن کاملCytogenetic Analysis of Referral Cases with Growth Failure and Clinical Suspicion of having Chromosomal Abnormality
Background and Objective: Failure to thrive (FTT) is a sign that describes a particular problem rather than a diagnosis and explain growth failure or more advanced failure to gain weight appropriately. The aim of this study was to determine the prevalence and type of chromosomal abnormalities in patients presented with FTT. Materials and Method: One hundred FTT cases with clinical impressio...
متن کاملگزارش یک مورد لوسمی مادرزادی و مروری بر مقالات
Although leukemia is the most common malignancy in childhood, congenital leukemia which manifests itself within the first 4 weeks of life is rare and accounts for less than 1% of all leukemias in childhood. Congenital leukemia should be differentiated from transient myeloproliferative disorder(TMD) which is noted in Down Syndrome. Among the reported patients, acute myeloid leukemia(AML) was...
متن کاملBone Marrow and Karyotype Findings of Patients with Pancytopenia in Southern Iran
Background: Pancytopenia is a manifestation of a wide range of disorders. The main prognostic factor for predicting outcome and response to treatment is based on the underlying cause. To detect the root cause of this problem, depending on other accompanied signs or symptoms, the need for bone marrow examination and other advanced work ups is different at least at the practical level. This study...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Blood
دوره 29 2 شماره
صفحات -
تاریخ انتشار 1967